Name: Tranylcypromine hydrochloride
Price: 196.00 USD

- Overview
  - Please contact us at for specific academic pricing.
    
    Background
    
    Tranylcypromine, also known as 2-PCPA, is a monoamine oxidase inhibitor (MAOI) that irreversibly inhibits MAO A and MAO B with the inhibition constant Ki values of 101.9 μM and 16 μM and the half maximal inhibition concentration IC50 values of 2.3 μM and 0.95 μM respectively [1].
    Tranylcypromine has also been found to potently and irreversibly inhibit histone demethylase lysine-specific demethylase 1 (LSD1), which is an amine oxidase homologue of MAO sharing similarities in the catalytic site with MAO A and B, in a time dependent and mechanism based manner with Ki and IC50 values of 242 μM and 20.7 μM respectively [1].
    
    [1] Schmidt DM, McCafferty DG. trans-2-Phenylcyclopropylamine is a mechanism-based inactivator of the histone demethylase LSD1. Biochemistry. 2007 Apr 10;46(14):4408-16. Epub 2007 Mar 17.
- Properties
  - Alternative Name
    
    (1R,2S)-2-phenylcyclopropanamine hydrochloride
    
    CAS Number
    
    1986-47-6
    
    Molecular Formula
    
    C9H11N·HCl
    
    Molecular Weight
    
    169.65
    
    Appearance
    
    A solid
    
    Purity
    
    99.17%
    
    Solubility
    
    ≥54.3 mg/mL in H2O; ≥54.9 mg/mL in EtOH; ≥7.8 mg/mL in DMSO
    
    Storage
    
    Desiccate at RT
    
    * For Research Use Only
- Reference
  - 1. Hoang N, Zhang X, et al. "New histone demethylase LSD1 inhibitor selectively targets teratocarcinoma and embryonic carcinoma cells." Bioorg Med Chem. 2018 Feb 7. pii: S0968-0896(17)31942-9. PMID:29439916

Tranylcypromine hydrochloride

Tranylcypromine hydrochloride

Background

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