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Overview
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Background
Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand.
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- Properties
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Overview
TOP1 Rabbit mAb
TOP1 Rabbit mAb
Catalog Number:
A001550325RED
Mfr. No.:
RDSA66922
Price:
$470
Size:
100μL
Quantity:
Add to Cart:
.