TNF-alpha, recombinant murine protein

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Background

Tumor Necrosis Factor-α (TNF-α) is a potent cytokine expressed as a transmembrane protein with 235 aa that is cleaved to the soluble monomer by TNF-α converting enzyme (TACE) and forms stable homotrimers. TNF-α is expressed in many cells and plays an important role in inflammation, viral replication, tumorigenesis, apoptosis, cell proliferation, differentiation, coagulation and lipid metabolism. TNF-α is mainly produced by macrophages when challenged with viruses or bacteria. TNF-α is cytotoxic for many tumor cells lines but induced activation, differentiation or proliferation in normal cells. Tumor necrosis factor receptor TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR are receptors for murine TNF-α.