Thymidine C-5 Dabcyl CED phosphoramidite

Thymidine C-5 Dabcyl CED phosphoramidite

Catalog Number:
NAS1056446CHE
Mfr. No.:
CLP-9906
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      • Overview

        • Please contact us at for specific academic pricing.

      • Properties
        • Categories
          Dabcyl Amidites and Supports
          Molecular Formula
          C63H76N9O10P
          Molecular Weight
          1150.310
          Shipping
          This material is sensitive to heat and moisture. It requires the fastest shipment possible.
      • Applications
        • Application Description
          Dabcyl phosphoramidites and solid supports:

          A molecular beacon probe has its natural fluorescence quenched in solution unless it is hybridized to the target sequence. Consequently, the design of a molecular beacon requires a fluorophore to be in one part of the sequence and the quencher molecule to be in another, with both molecules being separated from the oligonucleotide by a hydrocarbon spacer. The Dabcyl group has been found to be a universal quencher. Dabcyl CPGs and Dabcyl Amidites are used to prepare probes with the quencher blocking the 3’-terminus. 5’-Dabcyl Phosphoramidite locates the quencher at the 5’-terminus and Dabcyl-dT places it within the sequence, leaving the 3’-terminus available for polymerase extension.

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