Tetracycline Hydrochloride

- Overview
  - Tetracycline Hydrochloride is an antibiotic active against a wide range of gram-negative and gram-positive bacteria. The parent compound chlortetracycline was first isolated from Streptomyces aureofaciens in 1947. Soon after, other natural tetracyclines were isolated, including tetracycline, for which the family of molecules is named. The tetracyclines exert their antibiotic effect primarily by binding to the bacterial ribosome and halting protein synthesis. Upon binding the ribosome, the tetracyclines allosterically inhibit binding of the amino acyl-tRNA at the acceptor site, and protein synthesis ceases.
    
    Includes for 50 g:
    – 50 g Tetracycline Hydrochloride
    
    Please contact us at for specific academic pricing.
- Properties
  - CAS Number
    
    64-75-5
    
    Appearance
    
    Powder format
    
    Other Properties
    
    Specific optical rotation: -240 to -255°
    
    Storage
    
    4 °C.
    
    * This product is developed, designed and sold exclusively for Research purposes and in vitro use only (RUO). The product was not tested for use in diagnostics or for drug development, nor is it suitable for administration to humans or animals.
- Applications
  - Application Description
    
    Used to select for TetR transformed cells or other tetracycline resistance genes.
    Tetracycline hydrochloride is used in tetracycline controlled gene expression systems (gene switches) such as the Tet-on and Tet-off systems.
    Used for the prevention of bacterial contamination of cell cultures. Recommended for use in cell culture applications at 10 mg/L.

Datasheet

Tetracycline Hydrochloride

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