Name: Terazosin
Price: 180.00 USD

- Overview
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    Background
    
    Terazosin is an antagonist of α1-adrenergic receptor [1].Terazosin is a long acting and selective α1-adrenergic-antagonist drug. The major use of it is the treatment for benign prostatic hyperplasia since it can relax the prostatic smooth muscle. Terazosin is proved to be a safe and effective treatment and has few adverse effects [1]. Besiedes, terazosin is also used to treat for hypertension. It is found to significantly decrease blood pressure in patients with uncomplicated hypertension. It is also found to effect blood lipids beneficially. Terazosin modestly lowers blood total cholesterol, low density lipoprotein cholesterol and triglycerides as well as increases high density lipoprotein. The beneficial effects make terazosin more potent to prevent coronary heart disease [2].
    
    [1] Lepor H, Williford W O, Barry M J, et al. The efficacy of terazosin, finasteride, or both in benign prostatic hyperplasia. New England Journal of Medicine, 1996, 335(8): 533-540.
    [2] Grimm R H. alpha 1-antagonists in the treatment of hypertension. Hypertension, 1989, 13(5 Suppl): I131.
- Properties
  - Categories
    
    α1-adrenergic receptor antagonist
    
    Alternative Name
    
    [4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl]-(oxolan-2-yl)methanone
    
    CAS Number
    
    63590-64-7
    
    Molecular Formula
    
    C19H25N5O4
    
    Molecular Weight
    
    387.43
    
    Appearance
    
    A solid
    
    Purity
    
    99.64%
    
    Solubility
    
    ≥38.7 mg/mL in DMSO with gentle warming; insoluble in EtOH; insoluble in H2O
    
    Storage
    
    Store at -20°C
    
    SMILES
    
    COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(CC3)C(=O)C4CCCO4)N)OC
    
    * For Research Use Only