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Overview
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Background
Sitafloxacin is anantibiotic against gram-positive, gram-negativeand anaerobebacteria[1].
Sitafloxacin is a novel fluoroquinolone antibiotic with a broad antibacterial spectrum. It has activity against Enterobacterial species (gram-positive bacteria) with MIC50 values ranging from 0.008 to 1mg/ml and MIC90 values ranging from 0.015 to 2mg/ml. For the gram-negative bacteria, sitafloxacinis are found to be above eight-fold effective than ciprofloxacin against Acinetobacter spp. with MIC values ranging from 0.008 to 8mg/ml. Besides, sitafloxacinis are reported to inhibit anaerobic bacteria including Bacteroides species, Clostridium perfringens and Peptostreptococcus spp. with the MIC50 values ranging from 0.03 to 0.12mg/ml and MIC90 values ranging from 0.06 to 0.25 mg/ml [1].[1] Milatovic D1, Schmitz FJ, Brisse S, Verhoef J, Fluit AC. In vitro activities of sitafloxacin (DU-6859a) and six other fluoroquinolones against 8,796 clinical bacterial isolates.Antimicrob Agents Chemother. 2000 Apr;44(4):1102-7.
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