Name: Tedizolid
Price: 356.00 USD

- Overview
  - Tedizolid is an oxazolidone antibiotic. It is an oxazolidinone, but differs from other oxazolidinones by having a modified side chain at the C-5 position of the oxazolidinone nucleus which confers activity against certain linezolid-resistant pathogens. It also has an optimized C- and D-ring system that improves its potency via addiitonal binding site interactions. The compound was formerly known as Torezolid. Tedizolid is bacteriostatic against Gram-positive organisms. As with linezolid, Tedizolid is a weak, reversible MAO inhibitor.
    Tedizolid is slightly soluble in ethanol, DMSO, and DMF.
    
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    Background
    
    Tedizolid binds to the 23S rRNA of the 50S ribosomal subunit, preventing the formation of the 70S initiation complex and inhibiting protein synthesis.
- Properties
  - CAS Number
    
    856866-72-3
    
    Molecular Formula
    
    C17H15FN6O3
    
    Molecular Weight
    
    370.34
    
    Appearance
    
    White to off-white powder
    
    Solubility
    
    Slightly soluble in ethanol, DMSO and DMF
    
    Other Properties
    
    Source: Synthetic
    Purity Level: ≥99.0% (by HPLC)
    
    Storage
    
    2-8 °C
    
    * For research use only
- Applications
  - Application Description
    
    Spectrum: Tedizolid has activity against Gram-positive bacteria including MRSA and VRE, and linezolid-resistant strains with the cfr gene, in the absence of certain ribosomal mutations conferring reduced oxazolidinone susceptiibility. It has enhanced in vitro activity against Gram-positive aerobic bacteria. It also has activity against several Mycobacterium spp, including Mycobacterium tuberculosis and nontuberculous mycobacterium.
    
    Microbiology Applications: Tedizolid is four- to eightfold more potent in vivo compared to linezolid against staphylocci, enterococci, and streptococci, incuding MRSA and vancomycin-resistant enterococci (VRE) and linezolid-resistant phenotypes. Tedizolid resistance is most commonly caused by mutations of the peptidyl transferase center (PTC) binding site on the 50S subunit of the bacterial ribosome.

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