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TAT-ANK

TAT-ANK

Catalog Number:
P004516706LIF
Mfr. No.:
PEPTIDE-PP-270
Price:
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  • Size:
    1mg
    Quantity:
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      • Overview

        • Dll4-Notch1 inhibitor.
          TAT-ANK is a peptide derived from amino acid residues 179 191 of the G-protein coupled receptor kinase interacting protein-1 (GIT1) ankyrin domain, which are crucial for GIT1 binding to the Notch transcription repressor RBP-J. In vitro application of TAT-ANK significantly inhibits Delta-like 4 (Dll4) expression and Notch 1 activation in human umbilical vein endothelial cells (HUVECs) by competing with activated Notch1 binding to RBP-J, and in mouse models, TAT-ANK reduces tumour size through impairing tumour angiogenesis.

          Please contact us at for specific academic pricing.

      • Properties
        • Categories
          Cell Penetrating Peptides
          Alternative Name
          ANK peptide
          Molecular Formula
          C128H221N47O33
          Molecular Weight
          2946.45
          Appearance
          Freeze dried solid
          Purity
          >95% by HPLC
          Solubility
          Soluble in 50% DMSO and 50% sterile H2O
          Other Properties
          Sequence: H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Gln-Thr-Leu-Gln-Ala-Glu-Leu-Leu-Val-Val-Tyr-Gly-Ala-OH,YGRKKRRQRRRQTLQAELLVVYGA
          Storage
          Store dry, frozen and in the dark

          * Please note: this product can only be supplied to registered research and development facilities, and may be used for in vitro research use only, not for administration to humans or animals.

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