Name: (±)-Talinolol
Price: 388.00 USD

- Overview
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    Background
    
    (±)-Talinolol is a selective β1 adrenoceptor antagonist with cardioprotective and antihypertensive activity.
    β adrenoceptor antagonist is a class of medications that are particularly used to manage cardiac arrhythmias, and to protect the heart from a second heart attack after a first heart attack.
    By blocking β1-adrenergic receptors, (±)-talinolol delays the conduction of stimuli in the AV node, reduces the sino-atrial conduction time, and impedes the sinus node automaticity [1]. Pharmacokinetic data of the time course of plasma concentrations following intravenous infusion of 30 mg (±)-Talinolol revealed that the peak serum concentration (Cmax), the area under the serum concentration-time curve (AUC), and terminal elimination halflife (t1/2) were 631±95 ng/ml, 1433±153 ng×h/ml, and 10.6±3.3 h, respectively. Pharmacokinetic data of the time course of plasma concentrations following oral administration of 50 mg (±)-Talinolol revealed that the Cmax, the AUC, and the t1/2 were 168±67 ng/ml, 1321±382 ng×h/ml, and 11.9±2.4 h, respectively [2].
    
    [1] Abmann I. The actions of talinolol, a β1-selective beta blocker, in cardiac arrhythmia and acute myocardial infarction[J]. Current Medical Research and Opinion, 2008, 13(6): 325-342.
    [2] Trausch B, Oertel R, Richter K, et al. Disposition and bioavailability of the β1‐adrenoceptor antagonist talinolol in man[J]. Biopharmaceutics & Drug Disposition, 1995, 16(5): 403-414.
- Properties
  - Categories
    
    β1-selective adrenoceptor antagonist
    
    Alternative Name
    
    Cordanum; N-cyclohexyl-N'-[4-[3-[(1,1-dimethylethyl)amino]-2-hydroxypropoxy]phenyl]-urea
    
    CAS Number
    
    57460-41-0
    
    Molecular Formula
    
    C20H33N3O3
    
    Molecular Weight
    
    363.5
    
    Appearance
    
    A crystalline solid
    
    Purity
    
    Purity ≥95.00%
    
    Solubility
    
    ≤10mg/ml in ethanol;15mg/ml in DMSO;30mg/ml in dimethyl formamide
    
    Storage
    
    Store at -20°C
    
    SMILES
    
    O=C(NC1CCCCC1)NC2=CC=C(OCC(O)CNC(C)(C)C)C=C2
    
    * For Research Use Only