Name: Oligomycin Complex
Price: 209.00 USD

- Overview
  - Please contact us at for specific academic pricing.
    
    Background
    
    Target: ATP synthase
    GI50: 270 nM
    Oligomycin complex is a mixture of oligomycins A, B, and C. Oligomycin A is a selective inhibitor of ATP synthase, which can inhibit oxidative phosphorylation and all the ATP-dependent processes occurring on the coupling membrane of mitochondria, and induces apoptosis in a variety of cell types. Oligomycin B is a nonselective inhibitor of ATP synthases, which can reduce the rate of ATP depletion in myocardial ischemia.
    In Vitro: In A549, H1299, H1975, H520, 786-0, H838, and U87mG cancer cell lines, 100 ng/mL Oligomycin could completely inhibit OXPHOS phosphorylation activity and stimulate various levels of glycolysis gains [1]. Besides, 5 μg/mL Oligomycin could inhibit the F0 part of H+-ATP-synthase, and strongly suppress cytochrome c release and apoptosis in Hela cells induced by TNF [2]. Furthermore, Oligomycin could inhibit mitochondrial respiration, and sensitize melanoma cells to cisplatin treatment to inhibit cell invasion [3].
    In Vivo: no data available.
    Clinical trial: no data available.
    
    [1] Hao W, Chang C B, Tsao C, et al. Oligomycin-induced Bioenergetic Adaptation in Cancer Cells with Heterogeneous Bioenergetic Organization [J]. Journal of Biological Chemistry, 2010, 285 (17): 12647-12654.
    [2] Shchepina L A, Pletjushkina O Y, Avetisyan A V, et al. Oligomycin, inhibitor of the F0 part of H+-ATP-synthase, suppresses the TNF-induced apoptosis [J]. Oncogene, 2002, 21 (53): 8149.
    [3] Roesch A, Vultur A, Bogeski I, et al. Overcoming Intrinsic Multidrug Resistance in Melanoma by Blocking the Mitochondrial Respiratory Chain of Slow-Cycling JARID1Bhigh Cells [J]. Cancer Cell, 2013, 23 (6): 811-825.
- Properties
  - CAS Number
    
    1404-19-9
    
    Molecular Formula
    
    C45H74O11(Oligomycin A) C45H72O12(Oligomycin B) C45H74O10(Oligomycin C)
    
    Molecular Weight
    
    791.1 (Oligomycin A) 805.1 (Oligomycin B) 775.1 (Oligomycin C)
    
    Appearance
    
    A crystalline solid
    
    Purity
    
    Purity ≥95.00% (Mixture of A, B, C)
    
    Solubility
    
    ≤30 mg/mL in ethanol; 20 mg/mL in DMSO; 30 mg/mL in dimethyl formamide
    
    Storage
    
    Store at -20°C
    
    * For Research Use Only
- Reference
  - 1. Fangfang Wang, Zhang Dan, et al. "ALCAM regulates multiple myeloma chemoresistant side population." Cell Death Dis. 2022 Feb 10;13(2):136. PMID:35145058
    2. Beatriz Lapa, Ana Cristina Gonçalves, et al. "Acute myeloid leukemia sensitivity to metabolic inhibitors: glycolysis showed to be a better therapeutic target." Med Oncol. 2020 Jul 28;37(8):72. PMID:32725458

Oligomycin Complex

Oligomycin Complex

Background

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