Tacrolimus (FK506)

- Overview
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    Background
    
    Tacrolimus (FK506) is a potent and selective inhibitor of T-lymphocyte and the macrolide immunosuppressant [1].
    In vitro, Tacrolimus (FK506) has been reported to inhibit the interleukin 2(IL-2) production and the response of mixed lymphocyte culture. In addition, Tacrolimus (FK506) added to the cell cultures has been revealed to inhibit murine or human mixed lymphocyte reactivity and the generation of cytotoxic T cells. Furermor, Tacrolimus (FK506) has also been reported to dose-dependently suppress the production of various cytokines including IL-2, IL-3, IL-4, and γ-interferon, in response to different stimulis. Besides, Tacrolimus has shown its efficacy in the prevention of allograft rejection in animal transplant models. Tacrolimus has been found to be significantly efficient in experimental hepatic allografts, and has hepatotrophic properties [1].
    
    [1] Wallemacq PE1, Reding R. FK506 (tacrolimus), a novel immunosuppressant in organ transplantation: clinical, biomedical, and analytical aspects. Clin Chem. 1993 Nov; 39(11 Pt 1):2219-28.
- Properties
  - CAS Number
    
    104987-11-3
    
    Molecular Formula
    
    C44H69NO12
    
    Molecular Weight
    
    804.02
    
    Appearance
    
    A solid
    
    Purity
    
    98.00%
    
    Solubility
    
    ≥26.6 mg/mL in DMSO; insoluble in H2O; ≥84.5 mg/mL in EtOH
    
    Storage
    
    Store at -20°C
    
    * For Research Use Only
- Reference
  - 1. PENGYU JIA, NAN WU, et al. "Different roles of BAG3 in cardiac physiological hypertrophy and pathological remodeling." Transl Res. 2021 Jul;233:47-61. PMID:33578031
    2. Carsten Deppermann, Moritz Peiseler, et al. "Tacrolimus impairs Kupffer cell capacity to control bacteremia: why transplant recipients are susceptible to infection." Hepatology. 2020 Aug 6. PMID:32761929
    3. Souvik Dey, Alaa Eisa, et al. "Roles of glycogen synthase kinase 3 alpha and calcineurin in regulating the ability of sperm to fertilize eggs." FASEB J. 2020;34(1):1247–1269. PMID:31914663
    4. Peiffer BJ, Qi L, et al. "Activation of BMP Signaling by FKBP12 Ligands Synergizes with Inhibition of CXCR4 to Accelerate Wound Healing." Cell Chem Biol. 2019 May 16;26(5):652-661.e4. PMID:30827938
    5. Wang Z, Wang Y, et al. "Transient receptor potential channel 1/4 reduces subarachnoid hemorrhage-induced early brain injury in rats via calcineurin-mediated NMDAR and NFAT dephosphorylation." Sci Rep. 2016 Sep 19;6:33577. PMID:27641617

Tacrolimus (FK506)

Background

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