T-VDA K+

The potassium (K+) channel Targeted Venom Discovery ArrayTM is specifically designed to maximise discovery of new tools. K+ channels are important drug targets for a range of neurological disorders including pain. Venoms from scorpions, snakes and spiders are rich sources of new K+ tools. These targeted arrays contain pure venom fractions from 12, 24, 48 or 96 species optimised for identification of novel tools. Each array contains characterised venoms active on potassium channels from the literature to act as positive controls. The control venoms for T-VDAK+ include Dendroaspis polylepis (black mamba snake) where Dendrotoxin K [1] was discovered; Pandinus imperator (emperor scorpion) where several selective potassium channel tools have been discovered [2]; and Grammostola rosea (Chilean rose tarantula) which also contains a diverse collection of toxins including gating modifiers [3]. The other venom fractions making up the library have been specially selected by our drug discovery scientists to maximise novel hit potential.
• Venoms are supplied lyophilised in Echo qualified acoustic source plates (Labcyte Inc) and are useable on any SBS footprint liquid handling device or by hand.
• 384-well format has 200ng venom fraction per well, suggested dilution 20µl as hit fractions are typically active at 5µg/ml and below.
• 1536-well format also available.

Please contact us at for specific academic pricing.

Background

1. Smith L.A., Lafaye P.J., LaPenotiere H.F., Spain T., Dolly J.O. (1993). Cloning and functional expression of dendrotoxin K from black mamba, a K+ channel blocker. Biochemistry 32:5692-5697
2. Rogowski R.S., Collins J.H., O'Neill T.J., Gustafson T.A., Werkman T.R., Rogawski M.A., Tenenholz T.C., Weber D.J., Blaustein M.P. (1996). Three new toxins from the scorpion Pandinus imperator selectively block certain voltage-gated K+ channels. Mol. Pharmacol. 50:1167-1177
3. Swartz K.J., MacKinnon R. (1995). An inhibitor of the Kv2.1 potassium channel isolated from the venom of a Chilean tarantula. Neuron 15:941-949

Target Information