T-VDA ctox

Catalog Number:
TVDA089642VEN
Mfr. No.:
T-VDActox
Price:
  • Size:
    12 species, 2D HPLC, 1mg protein/fraction
    Quantity:
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      • Overview
        • The Cytotoxic Targeted Venom Discovery Array is specifically designed to maximise discovery of new tools. Cytotoxins are important drug tools for a range of applications including oncology and cellular mechanisms. Venoms from snakes (vipers and elapids) as well as scorpions are rich sources of new cytotoxins with various mechanisms. These targeted arrays contain pure venom fractions from 12, 24, 48 or 96 species optimised for identification of novel tools. Every array contains characterised venoms with cytotoxic activity from the literature to act as positive controls. The control venoms for T- VDActox include Naja nigricollis (black-necked spitting cobra) which contains three finger toxins [1]; Crotalus ruber (red diamondback rattlesnake) where the cytotoxic activity is from multiple enzymatic mechanisms [2]; and Scorpio maurus (Israeli gold scorpion) which also contains a diverse collection of cytotoxic peptides [3]. The other venom fractions making up the library have been specially selected by our drug discovery scientists to maximise novel hit potential.
          • Venoms are supplied lyophilised in Echo qualified acoustic source plates (Labcyte Inc) and are useable on any SBS footprint liquid handling device or by hand.
          • 384-well format has 200ng venom fraction per well, suggested dilution 20µl as hit fractions are typically active at 5µg/ml and below.
          • 1536-well format also available.

          Please contact us at  for specific academic pricing.

          Background

          1. Kalam, Y., Isbister, & G. K., Mirtschin, P., Hodgson, W.C., & Konstantakopoulos, N. (2010). Validation of a cell- based assay to differentiate between the cytotoxic effects of elapid snake venoms. Journal of Pharmacological and Toxicological Methods 1–6.
          2. Obrig, T. G., Louise, C. B., & Moran, T. P. (1993). Direct Cytotoxic Effects of Hemorrhagic Toxins from Crotalus ruber ruber and Crotalus atrox on Human Vascular Endothelial Cells, in Vitro. Microvascular Research 46, 412– 416.
          3. Abdel-Rahman, M. A., Omran, M. A. A., & Abdel-Nabi, I. M. (2010). Neurotoxic and cytotoxic effects of venom from different populations of the Egyptian Scorpio maurus palmatus. Toxicon 55, 298–306.

      • Properties
        • Storage
          Recommend storage at -20°C upon receipt. Lyophilised T-VDAs™ are shipped at ambient temperature, as they are stable for several weeks.
          Research Field
          Cytotoxins
      • Applications
        • Application Description
           T-VDAs™ can be used in any biochemical or cell based assay like any other compound array. The fractionated T-VDAs perform well in Phenotypic assays.
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