T-VDA acog

The Anticoagulant Targeted Venom Discovery Array is specifically designed to maximise discovery of new tools. Anticoagulants are important drug tools for a range of cardiovascular disorders including heart attack and stroke. Alongside leeches, venoms from snakes and jelly fish are also rich sources of new anticoagulants. Our targeted arrays contain pure venom fractions from 12, 24, 48 or 96 species optimised for identification of novel tools. Every array contains characterised venoms with anticoagulant activity from the literature to act as positive controls. The control venoms for T-VDA acog include Naja kaouthia (monocled cobra) which contains fibrinogenolytic toxins [1]; Aurelia aurita (moon jellyfish) where the fibrinogenolytic activity can completely liquefy clots [2]; and Hirudo verbana (medicinal leech) which famously also contains a diverse collection of anticoagulants [3]. The other venom fractions making up the library have been specially selected by our drug discovery scientists to maximise novel hit potential.
• Venoms are supplied lyophilised in Echo qualified acoustic source plates (Labcyte Inc) and are useable on any SBS footprint liquid handling device or by hand.
• 384-well format has 200ng venom fraction per well, suggested dilution 20µl as hit fractions are typically active at 5µg/ml and below.
• 1536-well format also available.

Please contact us at for specific academic pricing.

Background

1. Sekhar, C. C. & Chakrabarty, D. (2011). Fibrinogenolytic toxin from Indian monocled cobra (Naja kaouthia) venom. Journal of Biosciences 36, 355–361.
2. Rastogi, A., Biswas, S., Sarkar, A. & Chakrabarty, D. (2012). Anticoagulant activity of moon jellyfish (Aurelia aurita) tentacle extract. Toxicon 60, 719–723.
3. Kvist, S., Min. G.S. Siddall, M.E. (2013). Diversity and selective pressures of anticoagulants in three medicinal leeches (Hirudinida: Hirudinidae, Macrobdellidae). Ecology and Evolution 3, 918.