-SulfoBiotics- GYY4137 - Amerigo Scientific

- Overview
  - GYY4137 is one of the synthetic hydrogen sulfide donors derived from Lawsson’s reagent. It is water-soluble and releases H2S very slowly by hydrolysis in aqueous solutions. GYY4137 has shown distinct cellular effects such as anti-hypertensive, anti-atherosclerotic and anti-tumor activities in several reports.
    
    Please contact us at for specific academic pricing.
- Properties
  - CAS Number
    
    106740-09-4
    
    Molecular Formula
    
    C15H25N2O3PS2
    
    Molecular Weight
    
    376.47
    
    Appearance
    
    White to slightly yellow powder
    
    Purity
    
    ≥95.0% (HPLC)
    
    Storage
    
    0-5°C
    
    Shipping
    
    ambient temperature
    
    * For research use only
- Applications
  - Application
    
    Hydrogen Sulfide Donors
- Reference
  - 1) L. Li, M. Whiteman, Y. Y. Guan, K. L. Neo, Y. Cheng, S. W. Lee, Y. Zhao, R. Baskar, C-H. Tan, and P. K. Moore, “Characterization of a Novel, Water-Soluble Hydrogen Sulfide-Releasing Molecule (GYY4137): New Insights Into the Biology of Hydrogen Sulfide”, Circulation, 2008, 117, 2351.
    
    2) M. Whiteman, L. Li, P. Rose, C-H. Tan, D. B. Parkinson, and P. K. Moore, “The Effect of Hydrogen Sulfide Donors of Lipopolysaccharide-Induced Formation of Inflammatory Mediators in Macrophages”, Antioxid. Redox Signal., 2013, 19, 1749.
    
    3) Z. W. Lee, J. Zhou, C-S. Chen, Y. Zhao, C-H. Tan, L. Li, P. K. Moore, and L-W. Deng, “The Slow-Releasing Hydrogen Sulfide Donor, GYY4137, Exhibits Novel Anti-Cancer Effects In Vitro and In Vivo”, PLos One, 2011, 6, e21077.
    
    4) L. Li, B. Fox, J. Keeble, M. Salto-Tellez, P. G. Winyard, M. E. Wood, P. K. Moore, and M. Whiteman, “The complex effects of the slow-releasing hydrogen sulfide donor GYY4137 in a model of acute joint inflammation and in human cartilage cells”, J. Cell. Mol. Med., 2013, 17, 365.
    
    5) Z. Liu, Y. Han, L. Li, G. Meng, X. Li, M. Shirhan, M. T. Peh, L. Xie, S. Zhou, X. Wang, Q. Chen, W. Dai, C-H. Tan, S. Pan, P. K. Moore and Y. Ji, “The hydrogen sulfide donor, GYY4137, exhibits anti-atherosclerotic activity in high fat fed apolipoprotein E-/- mice”, Br. J. Pharmacology, 2013, 169, 1795.
    
    6) Satoru Sakuma, Saaya Minamino, MayaTakase, Yoshitaka Ishiyama, Hiroyuki Hosokura, Tetsuya Kohda, Yukino Ikeda, Yohko Fujimoto, "Hydrogen sulfide donor GYY4137 suppresses proliferation of human colorectal cancer Caco-2 cells by inducing both cell cycle arrest and cell death", Heliyon., 2019,doi.org/10.1016/j.heliyon.2019.e02244 .