Name: Sulfisoxazole
Price: 221.00 USD

- Overview
  - Sulfisoxazole is a bioactive small molecule and broad-spectrum sulfanilamide antibacterial agent with an oxazole substituent. It is an ETA selective endothelin receptor antagonist (ETAR antagonist). It is a synthetic analog of the natural compound para-aminobenzoic acid (PABA).
    
    Please contact us at for specific academic pricing.
    
    Background
    
    Sulfisoxazole competes with PABA for the bacterial dihydropteroate synthase, thus preventing incorporation of PABA into dihydrofolic acid, the precursor to folic acid. Folic acid is a coenzyme in the synthesis of purines and pyrimidines, leading to reduced cell growth and cell death. Unlike bacteria (and fungi/ plants) that synthesize their own folic acid, mammals do not, and thus are unaffected by PABA inhibitors.
- Properties
  - CAS Number
    
    127-69-5
    
    Molecular Formula
    
    C11H13N3O3S
    
    Molecular Weight
    
    267.30
    
    Appearance
    
    Solid
    
    Solubility
    
    soluble in DMSO. acetone. slightly soluble in alcohol
    
    Other Properties
    
    Source: Synthetic
    Purity Level: ≥98% (HPLC)
    
    Storage
    
    2-8°C
    
    * For research use only
- Applications
  - Application Description
    
    Spectrum: Broad-spectrum against a range of Gram-positive and Gram-negative bacteria including otitis media.
    
    Microbiology Applications: Sulfisoxazole is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (Sensi-Disc, from BD) against Gram- positive and Gram-negative bacteria.Sulfisoxazole has IC50 of 0.6 uM for ETA receptor, and 22 uM for rETA receptor. Sulfisoxazole was used in a novel engineered E. coli 12-member reporter panel of bioluminescent reporter stains, constructed using a novel non-antibiotic selection system, to survey environmental residues. The selectivity marker was developed based on the requirement for tryptophan, and folic acid-free medium was employed (Melamed et al, 2012).