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Overview
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SuCas12a2 nuclease is derived from the Sulfuricurvum sp. PC08-66 strain. Cas12a2 is a crRNA-guided RNA endonuclease, and its direct repeat sequence (DR) in crRNA is similar to that of Cas12a. Cas12a2 can specifically recognize and cleave the ssRNA target in the presence of a PFS sequence on the target ssRNA. In addition, compared to other Cas nucleases that, when specifically activated by the target, only non-specifically degrade ssDNA (e.g., Cas12a, Cas12b), or ssRNA (e.g., Cas13a), or both ssRNA and ssDNA (e.g., Cas12g), Cas12a2 has a more powerful trans-cleavage activity (i.e., collateral cleavage activity). This means that when Cas12a2 enzyme forms a ternary complex with crRNA and target RNA, it is activated to perform trans-cleavage activity against non-specific sequences of ssDNA, ssRNA, and dsDNA, cleaving any sequence of ssDNA, ssRNA, and dsDNA in the system.
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