Name: STAT5, Monoclonal Antibody
Price: 180.00 USD

Overview
- Sensitivity: Endogenous
  Target name: STAT5, monoclonal
  Area: Signaling
  
  Please contact us at for specific academic pricing.
  
  Background
  
  The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this gene in cells. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2013]
Properties
- Host
  
  Mouse
  
  Antibody Type
  
  monoclonal
  
  Isotype
  
  IgG1
  
  Reactivity
  
  Human, Mouse, Rat
  
  Clone
  
  mAb
  
  Storage
  
  Store at +4°C for short term storage. Long time storage is recommended at -20°C
  Phosphate buffered solution, pH 7.2, 20% Glycerol (pH7). 0.025% ProClin 300 was added as a preservative
  
  Molecular Weight
  
  90-95
  
  * For research use only.