Standard Chip NanoAu-MM

Cutting-edge FOPPR™ Biochip for generating standard curves with INB-D200 or INB-D800 Biomarker Analzer. Carboxyl group covalently attached to nano gold surface.

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Background

The unique & patented FOPPR™​​​​​​​ Technology is combining optical waveguides with noble metal nanoparticles for the sensitive and reliable detection of molecules. In FOPPR™, gold nanoparticles (AuNPs) are in close proximity to an unclad optical fiber. As light propagates within the optical fiber, total internal reflection (TIR) results in an evanescent field that induces the AuNPs to undergo particle plasmon resonance (PPR).

As a derivation of surface plasmon resonance (SPR), PPR of noble metal nanoparticles is the collective oscillation of conductive electrons at the nanoparticle surface in response to incident light of a particular wavelength. The extreme sensitivity of this optical property to changes in the surrounding environment makes FOPPR™ an ideal technology for monitoring real-time interactions between a wide range of molecular species, including but not limited to organic drugs, oligonucleotides, proteins, and viruses.

Molecular detection is achieved through the capture of free-flowing analytes by bioreceptors chemically bound to the FOPPR™ sensing surface. As target analytes are introduced to the sensing surface by the sample fluid, binding interactions between analytes and bioreceptors lead to a change of refractive index near the sensing surface. This refractive index change local to the sensing surface results in an immediate change in optical response proportional to the mass concentration of bound analytes. The label-free and biointeraction-based detection of FOPPR™ enables a wide range of applications in biochemical research, development and diagnostic processes.

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