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Overview
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Spinosad is a mixture of Spinosyn A and Spinosyn D. Spinosyns (macrocyclic lactones/macrolide insecticides) are extracted from the fermentation broth of Saccharopolyspora spinosa. This bacterial strain was isolated from a soil sample collected at a defunct sugar mill rum still in the Virgin Islands (Mertz and Yao, 1990). Spinosin A is produced in the greatest quantity, followed by Spinosyn D which differs from Spinosyn A by having a methyl group instead of a hydrogen atom at position C6 on the macrolide. The other 21 spinosyns are produced in very small quantities. Spinosad is used as a bio-insecticide as it shows efficacy against a variety of insects. Spinosyn A and D have the highest level of insecticidal activity. The Spinosyns do not have antibiotic effects on bacteria or fungi.
The spinosyns are soluble in organic solvents.Please contact us at for specific academic pricing.
Background
The compound is active by contact or ingestion, and its effect depends on the insect species and life stage. Spinosad affects the insect nervous system, acting as agonists of insect nicotinic acetylcholinesterase receptors (nAChRs) which leads to disruption of acetylcholine neurotransmission. It has secondary effects as a gamma-amino-butyric acid (GABA) neurotransmitter agonist that stimulates the nervous system.
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- Properties
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Overview