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Overview
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Endogenous galanin receptor 2/3 agonist.
Spexin, or neuropeptide Q, is an endogenous galanin receptor 2/3 agonist with EC50 values of 45 and 112 nM respectively, and no significant activity at galanin receptor 1. Spexin is a satiety inducing peptide which inhibits long chain fatty acid uptake by adipocytes and decreases food consumption in diet induced obese mice and rats. ? Spexin gene expression is markedly down regulated in obese human fat. Spexin also posseses anxiolytic properties.
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- Properties
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Overview