Name: SJB2-043
Price: 421.00 USD

- Overview
  - Please contact us at for specific academic pricing.
    
    Background
    
    SJB2-043 is a novel and potent inhibitor of USP1 with IC50 value of 0.544 μM [1]. Ubiquitin-specific protease 1 (USP1) is a deubiquitinating enzyme (DUB) and is a member of the ubiquitin-specific processing (UBP) family of proteases. It deubiquitinates a protein in the DNA repair pathway of the Fanconi anemia (FA) [1]. In the K562 cell line, SJB2-043 decreased USP1 levels in a dose-dependent way and caused degradation of the ID1 protein, which resulted from proteasomal degradation. Also, SJB2-043 decreased the levels of ID2 and ID3 proteins. Importantly, knockdown of USP1 inhibited cell growth and increased apoptosis. In primary AML cells, SJB2-043 inactivated USP1 and promoted ID 1 degradation. In primary human cord blood CD34+ cells, SJB2-043 in low micromolar levels inhibited cell growth. In HeLa cells, SJB2-043 increased the levels of Ub-FANCD2 and Ub-PCNA. And deubiquitination of FANCD2 is an important step in the BRCA/Fanconi anemia (FA) DNA repair pathway [1].
- Properties
  - Alternative Name
    
    2-phenylbenzo[f][1,3]benzoxazole-4,9-dione
    
    CAS Number
    
    63388-44-3
    
    Molecular Formula
    
    C17H9NO3
    
    Molecular Weight
    
    275.26
    
    Appearance
    
    A solid
    
    Purity
    
    98.88%
    
    Solubility
    
    insoluble in H2O; insoluble in EtOH; ≥4.62 mg/mL in DMSO
    
    Storage
    
    Store at -20°C
    
    * For Research Use Only

SJB2-043

SJB2-043

Background

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