signal transducer and activator of transcription 6 fragment

- Overview
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    Background
    
    Signal transducer and activator of transcription 6 fragment, (C54H81N13O15), a peptide with the sequence H2N-Ser-Tyr-Trp-Ser-Asp-Arg-Leu-Ile-Ile-OH, MW= 1152.3. STAT6 is a member of the STAT family of transcription factors(1). In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators(2). This protein plays a central role in exerting IL4 mediated biological responses(3). It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2), expression of cell surface markers, and class switch of immunoglobulins.
    
    1. Leek JP, Hamlin PJ, BellSM, LenchNJ(1997). "Assignment of the STAT6 gene (STAT6) to human chromosome band 12q13 by in situ hybridization". Cytogenet. Cell Genet. 79 (3–4): 208–9.
    2. Kisseleva T, Bhattacharya S, Braunstein J, Schindler CW (2002). "Signaling through the JAK/STAT pathway, recent advances and future challenges". Gene 285 (1–2): 1–24.
    3. Shimoda K, van Deursen J, Sangster MY, et al. (1996). "Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene". Nature 380 (6575): 630–3.
- Properties
  - Categories
    
    STAT6 transcription factor
    
    Alternative Name
    
    H2N-Ser-Tyr-Trp-Ser-Asp-Arg-Leu-Ile-Ile-OH
    
    Molecular Formula
    
    C54H81N13O15
    
    Molecular Weight
    
    1152.3
    
    Appearance
    
    A solid
    
    Purity
    
    99.79%
    
    Solubility
    
    ≥115.2 mg/mL in DMSO; insoluble in EtOH; ≥5.01 mg/mL in H2O with ultrasonic
    
    Storage
    
    Store at -20°C
    
    SMILES
    
    OCC(N)C(NC(CC1=CC=C(O)C=C1)C(NC(CC2=CNC3=C2C=CC=C3)C(NC(CO)C(NC(CC(O)=O)C(NC(CCCNC(N)=N)C(NC(CC(C)C)C(NC(C(C)CC)C(NC(C(CC)C)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O
    
    * For Research Use Only