Name: SHLP2
Price: 331.00 USD

- Overview
  - Binds to and activates CXCR7.
    SHLP2 is one of six small human in-like peptides (SHLP1 to 6) encoded by the 16S rRNA gene of the mitochondrial DNA genome, which is implicated in several biological processes such as ageing and oxidative stress. SHLP2 induces ?-Arrestin recruitment to CXCR7 with an EC50 of 0.9696M, and also binds directly to CXCR7, causing its internalization without affecting CXCR4. In vivo, administration of SHLP2 results in the suppression of food intake, activation of thermogenesis, and prevention of diet-induced obesity in mice. Activation of pro-opiomelanocortin (POMC) neurons by SHLP2 in the arcuate nucleus of the hypothalamus is involved in these processes. SHLP2 can also improve glucose tolerance and insulin sensitivity in vivo.
    
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- Properties
  - Categories
    
    Peptides
    
    Alternative Name
    
    Small humanin-like peptide 2
    
    Molecular Formula
    
    C142H214N36O35S
    
    Molecular Weight
    
    3015.58
    
    Appearance
    
    Freeze dried solid
    
    Purity
    
    >95% by HPLC
    
    Solubility
    
    Soluble in water
    
    Other Properties
    
    Sequence: H-Met-Gly-Val-Lys-Phe-Phe-Thr-Leu-Ser-Thr-Arg-Phe-Phe-Pro-Ser-Val-Gln-Arg-Ala-Val-Pro-Leu-Trp-Thr-Asn-Ser-OH,MGVKFFTLSTRFFPSVQRAVPLWTNS
    
    Storage
    
    Store dry, frozen and in the dark
    
    * Please note: this product can only be supplied to registered research and development facilities, and may be used for in vitro research use only, not for administration to humans or animals.

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