Seratrodast

- Overview
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    Background
    
    IC50: 7.4 nM for guinea pig platelets Seratrodast is a thromboxane A2 (TXA2) receptor antagonist.Thromboxane A2, a type of thromboxane, is produced by activated platelets and has prothrombotic properties, such as stimulating activation of new platelets and increasing platelet aggregation.In vitro: Seratrodast was found to inhibit the aggregation of guinea pig platelets induced by a prostaglandin endoperoxide analogue, U-44069 and the specific binding of another analogue, [3H]U-46619 to washed guinea pig platelets. Seratrodast could competitively inhibit the contraction of rabbit aorta and pig coronary arteries induced by U-44069. Seratrodast also inhibited the contraction of rabbit aorta induced by PGF2 alpha and the contraction of pig coronary arteries. However, seratrodast had no effect on the antiaggregatory effect of guinea pig platelets [1].In vivo: In experiments with guinea pigs, oral seratrodast at 0.1-1 mg/kg could dose-dependently inhibit the platelet aggregation induced by U-44069; the inhibition at 1 mg/kg was 100% at 1 hr and was 89% even at 24 hr after seratrodast administration [1].Clinical trial: So far, no clinical study has been conducted.
- Properties
  - Categories
    
    thromboxane A2 (TXA2) receptor (TP) antagonist
    
    Alternative Name
    
    AA2414,A-73001,ABT-001; ζ-(2,4,5-trimethyl-3,6-dioxo-1,4-cyclohexadien-1-yl)-benzeneheptanoic acid
    
    CAS Number
    
    112665-43-7
    
    Molecular Formula
    
    C22H26O4
    
    Molecular Weight
    
    354.4
    
    Purity
    
    98.00%
    
    Solubility
    
    ≥10.9 mg/mL in DMSO
    
    Storage
    
    Store at -20°C
    
    SMILES
    
    OC(CCCCCC(C1=CC=CC=C1)C(C(C(C)=C2C)=O)=C(C)C2=O)=O
    
    * For Research Use Only
- Reference
  - 1. Xiao J, Wang F, et al. "Targeting the COX2/MET/TOPK signaling axis induces apoptosis in gefitinib-resistant NSCLC cells." Cell Death Dis. 2019 Oct 14;10(10):777. PMID:31611604

Documents

COA (Certificate Of Analysis)

MSDS (Material Safety Data Sheet)

Datasheet

Seratrodast

Background

Documents

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