SepSphere™ Alprenolol Agarose

Alprenolol is an antagonist for β1 and β2 adrenergic receptors. Alprenolol agarose affinity chromatography was first introduced by Lefkowitz R. J. in 1979 (References 1 and 2) for the purification of erythrocyte β-adrenergic receptor based on ligand-receptor interactions. It is now routinely used for the purification of functionally active β1 and β2-adrenergic receptor. The SepSphere™ Alprenolol Agarose is composed of Agarose 4B Beads linked to alprenolol via a thiol ether linkage.

• Chemical Information
Alprenolol immobilized on agarose 4B beads through thiol ether linkage.

• Specification
Ligand: alprenolol
Physical appearance: suspension in 0.02% NaN3 solution.
Immobilization method: immobilized through the reaction of the double bond of alprenolol and S-alkyl-thiosulfate agarose.
Storage temp.: 2- 8 °C
Ligand concentration: 1 ~ 3 uMole per mL of settled beads by thiol assay
Matrix: agarose 4B (source: GE Life Science).
Spacer: 12 atoms
Particle size: 45-165 um

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