S-Methyl DM1 (S-Methyl Mertansine) Standard

S-methyl DM1 is the primary cellular or liver metabolite of ADC or other conjugates prepared with DM1. DM1 (mertansine) is a thiol-containing derivative of maytansine. It binds to tubulin and inhibits the assembly of microtubules. DM1 is used to prepare antibody-drug conjugates, such as trastuzumab emtansine (abbreviated as T-DM1). DM1 is not very stable in aqueous solution and can be oxidized or dimerized.

The S-methyl DM1 is a high purity product that can serve as a standard for HPLC and LC-MS/MS analysis. The product is formulated in DMSO solution, quantified by UV/HPLC using DM1 as standard/calibrator at 252 nm, and ready to use after dilution. Although S-methyl DM1 inhibits polymerization weaker than DM1, it can also be used as a stable control for ADC studies instead of DM1.

The product is sold as 1 vial of 1 mg (133 uL x 10 mM).

• Chemical Information
Chemical name: S-Methyl DM1 (S-Methyl Mertansine) Synonym: N2'-deacetyl-N2'-(3-methylthio-1-oxopropyl)-maytansine
Chemical formula: C36H50ClN3O10S
Molecular weight: 752.32 Da; CAS number: 912569-84-7

• Specifications
Physical appearance: solution
Storage temp.: -20 °C
Purity: ≥ 98 % by C18 HPLC
Concentration: 10 mM in DMSO (determined by UV/HPLC using DM1 as standard/calibrator at 252 nm)

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