Name: SC75741
Price: 287.00 USD

- Overview
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    Background
    
    SC75741 is a potent NF-κB inhibitor with EC50 value of 200 nM. NF-kB is a protein complex that regulates the expression of immunoreceptors, inflammatory cytokines and chemokines and is commonly regarded as a major antiviral factor. However, it has been shown that influenza A viruses exploit this signaling pathway for efficient replication [1].In MDCK cells, inhibitory potential of 5 uM SC75741 on virus replication is highest at later stages of infection. In the human alveolar type II epithelial cell line A549 infected with H5N1 and H7N7 viruses, SC75741 provoked an efficient reduction of virus titers in a dose-dependent way [1].In the lung of infected mice, SC75741 reduces viral replication and H5N1-induced IL6 and IP-10 expression. In addition, SC75741 also reduced cytokine production in vivo that is involved in hypercytokinemia mediated by influenza virus infection. Importantly, SC75741 exhibits a high barrier for virus variants [1].
    
    [1]. Ehrhardt C, Rückle A, Hrincius ER, et al. The NF-κB inhibitor SC75741 efficiently blocks influenza virus propagation and confers a high barrier for development of viral resistance. Cell Microbiol, 2013, 15(7): 1198-1211.
- Properties
  - Alternative Name
    
    (Z)-N-(6-benzoyl-1H-benzo[d]imidazol-2-yl)-2-(1-(thieno[3,2-d]pyrimidin-4-yl)piperidin-4-yl)thiazole-4-carbimidic acid
    
    CAS Number
    
    913822-46-5
    
    Molecular Formula
    
    C29H23N7O2S2
    
    Molecular Weight
    
    565.67
    
    Appearance
    
    A solid
    
    Purity
    
    98.00%
    
    Solubility
    
    insoluble in H2O; ≥12.56 mg/mL in EtOH with gentle warming and ultrasonic; ≥37.6 mg/mL in DMSO
    
    Storage
    
    Desiccate at -20°C
    
    * For Research Use Only

SC75741

SC75741

Background

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