Name: FPH2 (BRD-9424)
Price: 274.00 USD

- Overview
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    Background
    
    FPH2 (BRD-9424) is an inducer of functional proliferation of primary human hepatocytes [1].
    Human hepatocytes are capable of extensive expansion. With partial hepatectomy, the residual hepatocytes are able to proliferate and replace lost liver mass [1].
    FPH2 (BRD-9424) is an inducer of proliferation of primary human hepatocytes. In vitro, FPH2 induced functional proliferation of hepatocytes and might be useful for expanding mature human primary hepatocytes. In human primary hepatocytes, FPH2 increased the number of nuclei undergoing mitosis and hepatocyte nuclei count in a concentration dependent way. Also, FPH2 (40 μM) increased the area of hepatocyte colonies with more hepatocytes and Ki67-positive nuclei, which exhibited hepatocyte nuclear morphologies. In primary human hepatocytes from six additional cell sources, FPH2 increased hepatocytes expansion. FPH2 increased hepatocyte at a rate that is consistent with liver regeneration kinetics in vivo [1].
    
    Reference:[1]. Shan J, Schwartz RE, Ross NT, et al. Identification of small molecules for human hepatocyte expansion and iPS differentiation. Nat Chem Biol, 2013, 9(8): 514-520.
- Properties
  - Categories
    
    inducer of proliferation of primary human hepatocytes
    
    Alternative Name
    
    (Z)-N-(3-carbamoyl-1-ethyl-1H-pyrazol-4-yl)-N'-(5-chloro-2-methoxyphenyl)carbamimidothioic acid
    
    CAS Number
    
    957485-64-2
    
    Molecular Formula
    
    C14H16ClN5O2S
    
    Molecular Weight
    
    353.83
    
    Appearance
    
    A solid
    
    Purity
    
    98.00%
    
    Solubility
    
    ≥35.4 mg/mL in DMSO; insoluble in H2O; ≥1.77 mg/mL in EtOH with gentle warming and ultrasonic
    
    Storage
    
    Desiccate at -20°C
    
    SMILES
    
    CCN1C=C(N/C(S)=N/C2=C(OC)C=CC(Cl)=C2)C(C(N)=O)=N1
    
    * For Research Use Only
- Reference
  - 1. Yuan L, Liu X, et al. "Optimized HepaRG is a suitable cell source to generate the human liver chimeric mouse model for the chronic hepatitis B virus infection." Emerg Microbes Infect. 2018 Aug 10;7(1):144. PMID:30097574

Documents

COA (Certificate Of Analysis)

MSDS (Material Safety Data Sheet)

Datasheet

FPH2 (BRD-9424)

FPH2 (BRD-9424)

Background

Documents

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