Name: SB 203580 hydrochloride
Price: 180.00 USD

- Overview
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    Background
    
    SB203580 HCl is a specific inhibitor of p38-MAPKs with IC50 value of 0.6 μM [1].
    SB203580 is an inhibitor of p38-MAPKα and p38-MAPKβ. In neonatal myocytes, SB203580 prevented p38-MAPK from activating MAPKAPK2 with IC50 value of 70 nM. It also significantly suppressed MAPKAPK2 activation in by IL-1, osmotic stress or arsenite in KB cells. In neonatal rat ventricular myocytes, SB203580 inhibited JNK activity of activating c-Jun with IC50 value of 3-10 μM. Besides that, SB203580 affected the phosphorylation of small heat shock proteins caused by MAPKAPK2. It inhibited the IL-1-, chemical- or osmotic stress-stimulated HSP27 phosphorylation with IC50 value of < 1μM in KB cells [1, 2].
    
    [1] Cuenda A, Rouse J, Doza Y N, et al. SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1. FEBS letters, 1995, 364(2): 229-233.
    [2] Clerk A, Sugden P H. The p38-MAPK inhibitor, SB203580, inhibits cardiac stress-activated protein kinases/c-Jun N-terminal kinases (SAPKs/JNKs). FEBS letters, 1998, 426(1): 93-96.
- Properties
  - Alternative Name
    
    4-(4-(4-fluorophenyl)-2-(4-(methylsulfinyl)phenyl)-1H-imidazol-5-yl)pyridine hydrochloride
    
    CAS Number
    
    869185-85-3
    
    Molecular Formula
    
    C21H17ClFN3OS
    
    Molecular Weight
    
    413.9
    
    Appearance
    
    A solid
    
    Purity
    
    99.18%
    
    Solubility
    
    insoluble in EtOH; insoluble in H2O; ≥20.7 mg/mL in DMSO
    
    Storage
    
    Store at -20°C
    
    * For Research Use Only

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SB 203580 hydrochloride

SB 203580 hydrochloride

Background

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