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Overview
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Background
SATB1 is a crucial silencing factor contributing to the initiation of X inactivation mediated by Xist RNA that occurs during embryogenesis and in lymphoma (By similarity). Binds to DNA at special AT-rich sequences, the consensus SATB1-binding sequence (CSBS), at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcriptional repressor controlling nuclear and viral gene expression in a phosphorylated and acetylated status-dependent manner, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling.
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- Properties
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Overview
SATB1 Rabbit mAb
SATB1 Rabbit mAb
Catalog Number:
A001549903RED
Mfr. No.:
RDSA66501
Price:
$470
Size:
100μL
Quantity:
Add to Cart:
.