S-Methyl DM4 (S-Methyl Ravtansine) Standard

S-methyl DM4 is the primary cellular or liver metabolite of ADC or other conjugates prepared with DM4. DM4 (ravtansine) is a semisynthetic analogue of maytansine with a C3 ester side chain bearing a dimethyl hindered thiol substituent. It binds to tubulin and inhibits the assembly of microtubules. DM4 is used to prepare antibody-drug conjugates. DM4 is not very stable in aqueous solution and can be oxidized or dimerized. The S-methyl DM4 is a high purity product that can serve as a standard for HPLC and LC-MS/MS analysis. The product is formulated in DMSO solution, quantified by UV/HPLC using DM1 as standard/calibrator at 252 nm, and ready to use after dilution. Although S-methyl DM4 inhibits polymerization weaker than DM4, it can also be used as a stable control for the ADC studies instead of DM4.

The product is sold as 1 vial of 1 mg (126 uL x 10 mM).

• Chemical Information
Chemical name: S-Methyl DM4 (Ravatansine)
Chemical formula: C39H56ClN3O10S
Molecular weight: 794.40 Da; CAS number: 890654-03-2

• Specification
Physical appearance: solution
Storage temp.: -20 °C
Purity: ≥ 99 % by C18 HPLC
Concentration: 10 mM in DMSO (determined by UV/HPLC using DM1 as standard/calibrator at 252 nm)

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