Name: Rosiglitazone maleate
Price: 180.00 USD

- Overview
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    Background
    
    Rosiglitazone maleate is the maleic acid salt form of rosiglitazone, a potent insulin sensitizer, which is used for the treatment of diabetes. Rosiglitazone belongs to a group of compounds, thiazolidinediones (TZDs), which selectively ligate the nuclear transcription factor peroxisome-proliferator-activated receptor-γ (PPARγ). As a TZD, rosiglitazone improves the sensitivity of end organs to insulin through PPARγ activation which poteniates them to lower concentrations of blood glucose. Despite of its beneficial effects of targeting insulin resistance, recent studies has shown that rosiglitazone is associated with several moderate to severe adverse effects, including hemodilution, anemia, weight gain, and edema as well as increased risk for heart failure and myocardial ischemic events.
- Properties
  - Categories
    
    PPARγ agonist, high-affinity and selective, potent insulin sensitizer
    
    Alternative Name
    
    Avandia,Avandaryl,BRL 49653C,BRL-49653C; (Z)-but-2-enedioic acid;5-[[4-[2-[methyl(pyridin-2-yl)amino]ethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione
    
    CAS Number
    
    155141-29-0
    
    Molecular Formula
    
    C18H19N3O3S·C4H4O4
    
    Molecular Weight
    
    473.5
    
    Purity
    
    98.00%
    
    Solubility
    
    ≥23.7 mg/mL in DMSO; insoluble in H2O; ≥19 mg/mL in EtOH with ultrasonic
    
    Storage
    
    Store at -20°C
    
    SMILES
    
    CN(CCOC1=CC=C(C=C1)CC2C(=O)NC(=O)S2)C3=CC=CC=N3.C(=CC(=O)O)C(=O)O
    
    * For Research Use Only