Name: RKI-1447
Price: 258.00 USD

- Overview
  - Please contact us at for specific academic pricing.
    
    Background
    
    RKI-1447 is a potent inhibitor of ROCK 1 and 2 (Rho-associated protein kinase 1 and 2).
    ROCK is a serine-threonine kinase, which regulates cell shape and movement via acting on cytoskeleton.
    RKI-1447 specifically and dose-dependently inhibits ROCK1 and ROCK2. RKI-1447 inhibited the phosphorylation of the ROCK substrates MLC-2 and MYPT-1 in human cancer cells. However, it does not affect the phosphorylation of the AKT, MEK, and S6 kinase at a high concentrations of 10 μmol/L. It indicated a high specificity. Additionally, it was also observed that RKI-1447 selectively suppressed ROCK-mediated cytoskeleton re-organization following LPA stimulation, but does not affect PAK-meditated lamellipodia and filopodia formation following PDGF and Bradykinin stimulation. RKI-1447 inhibited migration, invasion and anchorage-independent tumor growth of breast cancer cells [1]
    In mouse model, tumors were monitored at the time of tumor onset and the beginning of treatment (once a day for 14 days) with vehicle (20% HPCD) or RKI-1447 (200 mg/kg/day), when tumor volumes reached 75 to 2,300 mm3. Tumors from mice treated with vehicle increased in average tumor volume of 68.3% but tumors from mice treated with the RKI-1447 increased in average tumor volume of only 8.8%. Thus, RKI-1447 inhibited mammary tumor growth by 87% [1].
- Properties
  - Alternative Name
    
    RKI 1447;RKI1447; 1-[(3-hydroxyphenyl)methyl]-3-(4-pyridin-4-yl-1,3-thiazol-2-yl)urea
    
    CAS Number
    
    1342278-01-6
    
    Molecular Formula
    
    C16H14N4O2S
    
    Molecular Weight
    
    326.37
    
    Appearance
    
    A solid
    
    Purity
    
    99.52%
    
    Solubility
    
    insoluble in H2O; ≥16.3 mg/mL in DMSO; ≥6.32 mg/mL in EtOH with gentle warming and ultrasonic
    
    Storage
    
    Store at -20°C
    
    * For Research Use Only

RKI-1447

RKI-1447

Background

We Also Recommend

Rotigotine hydrochloride

RS 127445