Name: Retapamulin
Price: 241.00 USD

- Overview
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    Background
    
    Retapamulin is a pleuromutilin antibiotic [1].Retapamulin is developed for topical treatment of skin infections which is mainly caused by gram-positive organisms, β-hemolytic streptococci and coagulase-negative staphylococci. Retapamulin is especially used against those drug resistance strains. In the in vitro studies, retapamulin demonstrates potent activity and a broad spectrum. It shows excellent antimicrobial activities against S. aureus, S. epidermidis, S. saprophyticus, S. pyogenes, S. agalactiae and Viridans group streptococci with MIC50 values of 0.06μg/ml, 0.06μg/ml, 0.12μg/ml, 0.008μg/ml, 0.016μg/ml and 0.03μg/ml, respectively. Retapamulin plays its antibiotic role through binding to a unique site of the bacterial ribosome [1, 2].
    
    [1] Jones R N, Fritsche T R, Sader H S, et al. Activity of retapamulin (SB-275833), a novel pleuromutilin, against selected resistant gram-positive cocci. Antimicrobial agents and chemotherapy, 2006, 50(7): 2583-2586.
    [2] Rittenhouse S, Biswas S, Broskey J, et al. Selection of retapamulin, a novel pleuromutilin for topical use. Antimicrobial agents and chemotherapy, 2006, 50(11): 3882-3885.
- Properties
  - Categories
    
    Pleuromutilin antibiotic, protein synthesis inhibitor
    
    Alternative Name
    
    (3aR,4R,5R,7S,8S,9R,9aS,12R)-8-hydroxy-4,7,9,12-tetramethyl-3-oxo-7-vinyldecahydro-4,9a-propanocyclopenta[8]annulen-5-yl 2-(((1R,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl)thio)acetate
    
    CAS Number
    
    224452-66-8
    
    Molecular Formula
    
    C30H47NO4S
    
    Molecular Weight
    
    517.76
    
    Appearance
    
    A solid
    
    Purity
    
    98.00%
    
    Solubility
    
    insoluble in H2O; ≥114.8 mg/mL in EtOH; ≥16.15 mg/mL in DMSO
    
    Storage
    
    Store at -20°C
    
    SMILES
    
    O[[email protected]]([[email protected]](C)(C=C)C1)[[email protected]](C)[[email protected]]2(CCC3=O)[[email protected]]3([H])[[email protected]@]([[email protected]@H]1OC(CSC4C[[email protected]](CC5)([H])N(C)[[email protected]]5([H])C4)=O)(C)[[email protected]](C)CC2
    
    * For Research Use Only

Documents

COA (Certificate Of Analysis)

MSDS (Material Safety Data Sheet)

Datasheet

Retapamulin

Retapamulin

Background

Documents

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