Name: Recombinant Human Von Hippel-Lindau Protein
Price: Inquiry

- Overview
  - Recombinant Human Von Hippel-Lindau Protein b-domain produced in E. Coli is a single, non-glycosylated polypeptide chain containing 174 amino acids (1-154) & having a molecular mass of 19.2 kDa. The Von Hippel-Lindau antigen is fused to 20 amino acid His-Tag at N-terminus and purified by proprietary chromatography techniques. Von Hippel-Lindau disease is a dominant inherited syndrome characterized by the predisposition to develop various kinds of benign and malignant tumors, including clear cell renal carcinomas, pheochromocytomas and hemangioblastomas of the central nervous system and retina. VHL syndrome is caused by germline mutation in the VHL tumor suppressor, and VHL tumors are associated with loss or mutation of the remaining wild-type allele. VHL has two domains: a roughly 100-residue NH2-terminal domain rich in b sheet (b-domain) and a smaller a-helical domain (a-domain), held together by two linkers and a polar interface. VHL protein is also involved in the degradation of hypoxia-inducible factor (HIF).
    
    Please contact us at for specific academic pricing.
- Properties
  - Protein Name
    
    Von Hippel-Lindau disease tumor suppressor, pVHL, Protein G7, VHL, RCA1, VHL1, HRCA1.
    
    Source
    
    E. coli
    
    Type
    
    Recombinant Proteins
    
    Purification
    
    Greater than 95.0% as determined by SDS-PAGE.
    
    Formulation
    
    The Von Hippel-Lindau Protein contains 1x PBS pH-7.4, 2mM EDTA, and 1mM DTT.
    
    Storage
    
    Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.
    
    * For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Recombinant Human Von Hippel-Lindau Protein

Recombinant Human Von Hippel-Lindau Protein

We Also Recommend

Recombinant Human Vanin

Recombinant Human Vimentin

Recombinant Human Vimentin, GST Tag