Recombinant Human Ubiquitin Fusion Degradation 1 Like

Recombinant Human Ubiquitin Fusion Degradation 1 Like

Catalog Number:
P001414398ABE
Mfr. No.:
Abe32-5185
Price:
  • Size:
    10 µg
    Quantity:
    Add to Cart:
      • Overview
        • UFD1L Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 330 amino acids (1-307) and having a molecular mass of 36.9kDa. UFD1L is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques. UFD1L forms a complex with two other proteins, nuclear protein localization-4 and valosin-containing protein, and this complex is necessary for the degradation of ubiquitinated proteins. In addition, this complex controls the disassembly of the mitotic spindle and the formation of a closed nuclear envelope after mitosis. Mutations in this gene have been associated with Catch 22 syndrome as well as cardiac and craniofacial defects. Alternative splicing results in multiple transcript variants encoding different isoforms. A related pseudogene has been identified on chromosome 18.

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      • Properties
        • Protein Name
          Ubiquitin Fusion Degradation 1 Like (Yeast), UB Fusion Protein 1, Ubiquitin Fusion Degradation Protein 1 Homolog, UFD1.
          Source
          E. coli
          Type
          Recombinant Proteins
          Purification
          Greater than 85% as determined by SDS-PAGE.
          Formulation
          The UFD1L solution contains 20mM Tris-HCl buffer (pH 8.0), 0.1M NaCl, 1mM DTT and 30% glycerol.
          Storage
          Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.

          * For Research Use Only. Not for use in diagnostic/therapeutics procedures.

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