Name: Recombinant Human THAP Domain Containing, Apoptosis Associated Protein 1
Price: Inquiry

- Overview
  - THAP1 Human Recombinant produced in E. Coli is a single, non-glycosylated polypeptide chain containing 237 amino acids (1-213 a.a) and having a molecular mass of 27.5kDa. THAP1 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques. THAP domain-containing protein 1 (THAP1) is a 213 amino acid protein which is restricted to the nucleoplasm and contains one THAPtype zinc finger, a conserved DNA-binding domain. THAP1 is a DNA-binding transcription regulator which regulates endothelial cell proliferation and G1/S cell-cycle progression. In addition, THAP1 has a pro-apoptopic activity by potentiating both serum-withdrawal and TNF-induced apoptosis. THAP1 protein colocalizes with the apoptosis response protein PAWR/PAR-4 in promyelocytic leukemia (PML) nuclear bodies, and serves as a proapoptotic factor which connects PAWR to PML nuclear bodies.
    
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- Properties
  - Protein Name
    
    THAP domain-containing protein 1, THAP1, DYT6.
    
    Source
    
    E. coli
    
    Type
    
    Recombinant Proteins
    
    Purification
    
    Greater than 85.0% as determined by SDS-PAGE.
    
    Formulation
    
    THAP1 protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 2M Urea, 10% glycerol, 1mM DTT and 0.2M NaCl.
    
    Storage
    
    Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.
    
    * For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Recombinant Human THAP Domain Containing, Apoptosis Associated Protein 1

Recombinant Human THAP Domain Containing, Apoptosis Associated Protein 1

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