Recombinant Human T-cell Surface Glycoprotein CD4/sCD4 (C-6His)

Recombinant Human T-cell Surface Glycoprotein CD4/sCD4 (C-6His)

Catalog Number:
P001413038ABE
Mfr. No.:
Abe32-9335
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      • Overview
        • CD4 is an approximately 55 kDa type I transmembrane glycoprotein that is expressed predominantly on thymocytes and a subset of mature T lymphocytes. It is a standard phenotype marker for the identification of T cell populations. Mature human CD4 consists of a 371 amino acid extracellular region containing four immunoglobulin-like domains, a 22 aa transmembrane segment, and a 40 aa cytoplasmic domain. CD4 is expressed along with CD8 on double positive T cells during their development in the thymus. CD4 binds directly to MHC class II molecules on antigen presenting cells (10). This interaction contributes to the formation of the immunological synapse which is focused around the TCR-MHC class II-antigenic peptide interaction. CD4 also functions as a chemotactic receptor for IL-16 and, in human, as a co-receptor for the gp120 surface glycoprotein of HIV-1.

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      • Properties
        • Protein Name
          T-cell surface glycoprotein CD4; T-cell surface antigen T4/Leu-3; sCD4
          Source
          Human cells
          Type
          Recombinant Proteins
          Formulation
          Lyophilized from a 0.2 µm filtered solution of PBS, pH7.4.

          * For Research Use Only. Not for use in diagnostic/therapeutics procedures.

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