Name: Recombinant Human Neutrophil Matrix metalloproteinase-8/MMP8 (C-10His)
Price: Inquiry

- Overview
  - Matrix metalloproteinases (MMPs) are a family of zinc and calcium dependent endopeptidases with the combined ability to degrade all the components of the extracellular matrix. MMP8 (neutrophil collagenase) is expressed in neutrophils, where it is stored in specific granules. MMP8 release from the neutrophils is stimulated by various factors such as interleukins 1 and 8, TNF--Alpha and GM-CSF. MMP8 is capable of cleaving types I, II and III triple-helical collagen, gelatin peptides, fibronectin, proteoglycans, aggrecan, serpins, Beta-casein and peptides such as angiotensin and substance P. In addition to its function in phagocytosis, MMP8 has a high capacity for infiltrating connective tissue, and is implicated in the breakdown of the extracellular matrix in diseases such as rheumatoid arthritis. Structurally, MMP8 consists of several domains: a pro-domain that is cleaved upon activation, a catalytic domain containing the zinc-binding site, a short hinge region and a hemopexin-like domain. MMP8 is heavily glycosylated.
    
    Please contact us at for specific academic pricing.
- Properties
  - Protein Name
    
    Neutrophil collagenase; Matrix metalloproteinase-8; MMP-8; PMNL collagenase; PMNL-CL; MMP8; CLG1
    
    Source
    
    Human cells
    
    Type
    
    Recombinant Proteins
    
    Formulation
    
    Lyophilized from a 0.2 µm filtered solution of 50mM Tris-HCl, 10mM CaCl2, 150mM NaCl, pH7.5.
    
    * For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Recombinant Human Neutrophil Matrix metalloproteinase-8/MMP8 (C-10His)

Recombinant Human Neutrophil Matrix metalloproteinase-8/MMP8 (C-10His)

We Also Recommend

Recombinant Human Dentin Matrix Acidic Phosphoprotein 1/DMP-1 (C-6His)

Recombinant Human Follitropin Subunit Beta/FSHB (C-6His)

Recombinant Mouse Transferrin Receptor Protein 1/TfR (N-8His)