Name: Recombinant Human SPRY Domain-Containing SOCS Cox Protein 2
Price: Inquiry

- Overview
  - SPSB2 Human Recombinant produced in E. Coli is a single, non-glycosylated polypeptide chain containing 287 amino acids (1-263 a.a) and having a molecular mass of 31.2kDa. SPSB2 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques. SPRY Domain-Containing SOCS Cox Protein 2 (SPSB2) belongs to a suppressor of cytokine signaling (SOCS) family, and is a member of the subfamily of proteins containing a central SPRY (repeats in splA and RyR) domain and a C-terminal SOCS box. SPSB2 is present in a gene-rich cluster on chromosome 12p13 in the vicinity of the CD4 antigen and triosephosphate isomerase genes. SPSB2 is apparent substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and ensuing proteasomal degradation of target proteins.
    
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- Properties
  - Protein Name
    
    SPRY domain-containing SOCS box protein 2, SSB-2, Gene-rich cluster protein C9, SPSB2, GRCC9, SSB2, GRCC9.
    
    Source
    
    E. coli
    
    Type
    
    Recombinant Proteins
    
    Purification
    
    Greater than 85.0% as determined by SDS-PAGE.
    
    Formulation
    
    SPSB2 protein solution (0.5mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 20% glycerol and 1mM DTT.
    
    Storage
    
    Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.
    
    * For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Recombinant Human SPRY Domain-Containing SOCS Cox Protein 2

Recombinant Human SPRY Domain-Containing SOCS Cox Protein 2

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