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Recombinant Human ROS1 (N-GST tag)

Recombinant Human ROS1 (N-GST tag)

Catalog Number:
E001278532APP
Mfr. No.:
Z500349
Price:
$672
  • Size:
    10 µg
    Quantity:
    Add to Cart:
    Add to Cart
      • Overview

        • ROS1 is a proto-oncogene and member of the sevenless subfamily of tyrosine kinase insulin receptor genes. ROS1 is highly-expressed in a variety of tumor cell lines and functions as a growth or differentiation factor receptor. The FIG gene can fuse with the ROS1 gene in glioblastoma cell lines. The resulting ROS1/FIG fusion protein is a constitutively activated tyrosine kinase. Direct interaction of ROS1 and the phosphatase SHP-1 can lead to efficient downregulation of ROS1-mediated signaling. Binding sites in the ROS1 cytoplasmic domain display high affinity binding to the SHP-1 N-terminal SH2 domain.

          Please contact us at for specific academic pricing.

      • Properties
        • Name
          c-ros-1; MCF3; ROS
          Source
          Insect cells
          Type
          Recombinant Proteins
          Formulation
          50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
          Storage
          Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
          Molecular Weight
          82.0 kDa
          Class
          Active Kinases

          * For research use only. Not for diagnostic or therapeutic use.

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