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Overview
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RAB4A produced in E. Coli is a single, non-glycosylated polypeptide chain containing 238 amino acids (1-218 a.a) and having a molecular mass of 26.5kDa. RAB4A is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques. RAB4A is a member of the small GTPase superfamily. RAB4A interacts with STX4, RAB11FIP1, RABEP1, CD2AP and KIF3B. In addition, Rab4 is involved in the translocation of glucose transporter (Glu4) in adipocytes in response to insulin. Rab4 overexpression causes a redistribution of receptors on plasma membrane versus endocytic compartments.
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