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Recombinant Human PI3K (p110 alpha/p85 alpha) (N-His tag)

Recombinant Human PI3K (p110 alpha/p85 alpha) (N-His tag)

Catalog Number:

E001278472APP

Mfr. No.:

Z500289

Price:

$768

Size:

10 µg

Quantity:

Add to Cart:

- Overview
  - The PI3K comprises of a 110 kDa catalytic subunit and a 85 kDa regulatory subunit. A number of isoforms of the 110 kDa catalytic subunit and the 85 kDa regulatory subunit exist in cells. The p110a catalytic subunit (PIK3CA) is frequently mutated or amplified in a variety of cancers including ovarian and colon and this protein is one of the PI3K mutants. PIK3CA gene copy number is increased in over 30% of ovarian cancers and this leads to increased PI3-kinase activity. Furthermore, the activity of p110a is essential for vascular development and inactivation of p110a leads to severe defects in angiogenic sprouting and vascular remodeling.
    
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- Properties
  - Name
    
    p110α: PIK3CA, MGC142161, MGC142163, p110-alpha p85α: PIK3R1, GRB1, p85-ALPHA
    
    Source
    
    Insect cells
    
    Type
    
    Recombinant Proteins
    
    Formulation
    
    50mM sodium, pHosphate, pH 7.0, 300mM NaCl, 150mM imidazole, 0.1mM PMSF, 0.25mM DTT, 25% glycerol.
    
    Storage
    
    Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
    
    Molecular Weight
    
    111.0kDa, 86.0kDa
    
    Class
    
    Active Kinases
    
    * For research use only. Not for diagnostic or therapeutic use.

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