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Recombinant Human PDHK1 (N-GST tag)

Recombinant Human PDHK1 (N-GST tag)

Catalog Number:

E001278474APP

Mfr. No.:

Z500279

Price:

$672

Size:

10 µg

Quantity:

Add to Cart:

- Overview
  - PDHK1 or Pyruvate Dehydrogenase Kinase 1 is a member of the PDHK family that phosphorylate and inactivate the Pyruvate Dehydrogenase (PDH). PDH is a mitochondrial multienzyme complex that catalyzes the oxidative decarboxylation of pyruvate and is one of the major enzymes responsible for the regulation of homeostasis of carbohydrate fuels in mammals. PDHK1 is an important regulator of PDH in clonal β-cells and the activity of PDHK1 and PDH are important for efficient metabolic coupling. Maintaining low PDHK1 expression/activity and keeping PDH in a dephosphorylated and active state, is important for β -cells to achieve the metabolic flux rates necessary for maximal glucose-stimulated insulin secretion.
    
    Please contact us at for specific academic pricing.
- Properties
  - Name
    
    PDK1
    
    Source
    
    Insect cells
    
    Type
    
    Recombinant Proteins
    
    Formulation
    
    50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
    
    Storage
    
    Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
    
    Molecular Weight
    
    70.0 kDa
    
    Class
    
    Active Kinases
    
    * For research use only. Not for diagnostic or therapeutic use.

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