Name: Recombinant Human PD-L1 Fc Fusion Protein (Active)
Price: Inquiry

- Overview
  - PD-L1 (CD274/B7-H1) is a critical membrane-bound costimulatory molecule belongs to the B7 superfamily that inhibits immune responses through its receptor, PD-1 and PD-L1 play a key role in the pathogenesis of inflammatory diseases (programmed death 1). It is widely expressed in the mononuclear phagocyte system (MPS), may co-stimulate T cells and regulates inflammatory responses. PD-L1 exerts inflammation regulatory functions via a negative co-stimulatory effect on T cell functions to inhibit cytokine secretion, facilitate apoptosis of activated T cells and induce T cell anergy. Aberrant expression and dysregulation of CD274 have been reported during bacterial infection, inflammation and in numerous autoimmune diseases.
    
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- Properties
  - Protein Name
    
    B7 homolog 1, CD274, B7H1, PDCD1L1, PDCD1LG1, PDL1
    
    Source
    
    CHO-K1
    
    Type
    
    Recombinant Proteins
    
    Purification
    
    99% Purity SDS -PAGE and HPLC.
    
    Formulation
    
    Lyophilized sterile PBS, 5% trehalose and 0.01% tween 80 are added as protectant before lyophilization.
    
    Storage
    
    Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
    
    * For Research Use Only. Not for use in diagnostic/therapeutics procedures.
- Applications
  - Application
    
    Functional Assay; ELISA; FACS; WB
    
    Application Description
    
    Functional assay: Measured by its binding ability in a functional FLOW . Binding assay was tested using CHO-K1/PD-1 (cat no. 14-500ACL).

Recombinant Human PD-L1 Fc Fusion Protein (Active)

Recombinant Human PD-L1 Fc Fusion Protein (Active)

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