Name: Human CD80 Recombinant Fc fusion Protein (Active)
Price: Inquiry

- Overview
  - The B-lymphocyte activation antigen B7-1 (referred to as B7), also known as CD80, is a member of cell surface immunoglobulin superfamily and is expressed on the surface of antigen-presenting cells including activated B cells, macrophages and dendritic cells. As costimulatory ligands, B7-1 which exists predominantly as dimer and the related protein B7-2, interact with the costimulatory receptors CD28 and cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) expressed on T cells, and thus constitute one of the dominant pathways that regulate T cell activation and tolerance, cytokine production, and the generation of CTL. The B7/CD28/CTLA4 pathway has the ability to both positively and negatively regulate immune responses. CD80 is thus regarded as promising therapeutic targets for autoimmune diseases and various carcinomas. Cancer Immunotherapy Co- inhibitory Immune Checkpoint Targets Immune Checkpoint Immune Checkpoint Detection Human extracellular domain CD80 (B7-1) Fc fusion protein. This protein is expressed in CHO-K1 cells and purified using protein G colomn. Protein MW 53 kDa but SDS it runs arround 65 kDa due to glycosylation.
    
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- Properties
  - Protein Name
    
    T-lymphocyte activation antigen CD80, Activation B7-1 antigen, BB1, CTLA-4 counter-receptor B7.1, B7, CD28LG, CD28LG1, LAB7
    
    Type
    
    Recombinant Proteins
    
    Purification
    
    95% Purity SDS-PAGE and HPLC
    
    Formulation
    
    Lyophilized from sterile PBS, 5% trehalose and 0.01% tween 80 are added as protectant before lyophilization. Reconstitutes sterile water.
    
    Storage
    
    Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
    
    Endotoxin
    
    <1.0EU per ug of the protein as determin by the LAL method.
    
    * For Research Use Only. Not for use in diagnostic/therapeutics procedures.
- Applications
  - Application
    
    Functional Assay; ELISA; FACS; WB
    
    Application Description
    
    Measured by its binding ability in a functional FLOW assay. Binding assay was tested using CHO-K1/CTLA4 cell line (cat no. 14-506ACL).

Human CD80/hFc recombinant protein. 0.5 ug protein was run on a 4-20% SDS-PAGE gel followed by Coomassie blue staining.

Human CD80 Recombinant Fc fusion Protein (Active)

Human CD80 Recombinant Fc fusion Protein (Active)

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