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Overview
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PKNOX1 Human Recombinant produced in E. Coli is a single, non-glycosylated polypeptide chain containing 456 amino acids (1-436 a.a) and having a molecular mass of 49.7kDa. PKNOX1 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques. PBX/Knotted 1 Homeobox 1 (PKNOX1) is a DNA-binding factor which takes part in the regulation of the transcriptional activity of AP-1 containing promoters. PKNOX1, which is also known as UEF3, PRP-1 and p64, is a Hmeobox protein. PKNOX1 forms stable complexes containing PBX proteins which synergize with AP-1 binding factors in order to amplify transcription of the urokinase gene.
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Overview