Name: Recombinant Human Phospholipid Scramblase 3
Price: Inquiry

- Overview
  - PLSCR3 Human Recombinant produced in E. Coli is a single, non-glycosylated polypeptide chain containing 288 amino acids (1-265 a.a) and having a molecular mass of 30.9kDa. PLSCR3 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques. PhospholipidScramblase 3, (PLSCR3) may mediate accelerated ATP-independent bidirectionaltransbilayer migration of phospholipids upon binding calcium ions which resultsin a loss of phospholipid asymmetry in the plasma membrane. PLSCR3may play a key role in the initiation of fibrin clot formation, in theactivation of mast cells and in the recognition of apoptotic and injured cellsby the reticuloendothelial system. In addition, PLSCR3 seems to play a role inapoptosis, throughtranslocation of cardiolipin from the inner to the outer mitochondrial membranewhich promotes BID recruitment and enhances tBid-induced mitochondrial damages. Among the diseases associated with PLSCR3 are brain ischemia, and ischemia.
    
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- Properties
  - Protein Name
    
    Phospholipid scramblase 3, PL scramblase 3, Ca(2+)-dependentphospholipid scramblase 3.
    
    Source
    
    E. coli
    
    Type
    
    Recombinant Proteins
    
    Purification
    
    Greater than 90% as determined by SDS-PAGE.
    
    Formulation
    
    PLSCR3 protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 10% glycerol and 0.4M urea.
    
    Storage
    
    Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please avoid freeze thaw cycles.
    
    * For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Recombinant Human Phospholipid Scramblase 3

Recombinant Human Phospholipid Scramblase 3

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